ILIAS Biologics ILIAS Therapeutics

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Technology

ILIAS is the Leader of Next-Generation Exosome Therapeutics.

About Exosome

Exosomes are extracellular vesicles released by cells in the body. Exosomes act as intercellular
messengers delivering a variety of materials including RNA, Proteins, etc.

Extracellular vesicles, secreted by almost every cells, are classified into three groups depending on their size;
exosome(50 – 200nm), microvesicle (200 - 1000nm), apoptotic body(800 – 5000nm).

Exosomes are produced by unique mechanisms, compared to the other types of extracellular vesicles. They invaginate into an endosome, then secreted
from cell surface to extracellular space after completion of maturation period in endosome. This whole process endows exosomes certain characteristics
as follows; first, defined range of size. Second, incorporation of certain types of membrane proteins. Lastly, inclusion of various cell-derived molecules,
such as proteins, lipid, and RNA, in their lumen. Exosomes can modify biological functions of recipient cells upon arrival either by cellular uptake into
cytoplasm or protein-to-protein signaling at the cell surface.

Exosome-based Drug-Delivery System

Although many drug delivery systems have been tested, the limitations of therapeutic modalities have rendered many of them intractable.
Exosomes as a drug delivery vehicle have exclusive advantages over others as follows;

  • Advantages01

    Exosomes can evade host immune
    system, thereby increasing stability of
    therapeutic molecules.

  • Advantages02

    Exosomes can mediate intercellular
    communication between cells, thereby
    suitable for intracellular drug delivery.

  • Advantages03

    Exosomes are derived from cells of
    live animal, thereby it has high
    biocompatibility.

  • Advantages04

    Exosomes can pass through
    blood-brain-barrier, thereby it has high
    potential to be a successful treatment
    of neurological disease.

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